Clean Smoke

Study Supports New Theory for Nicotine`s Protective Effect against Neurodegenerative Disorders

Tampa, FL (March 15, 2004) – While the health risks of tobacco are well known, several studies have shown that people with a history of cigarette smoking have lower rates of neurodegenerative diseases like Parkinson`s and Alzheimer`s disease. However, the explanations for nicotine`s neuroprotective effects continue to be debated.

Now a team of neuroscientists at the University of South Florida College of Medicine presents new evidence of an anti-inflammatory mechanism in the brain by which nicotine may protect against nerve cell death. Their study was published today in the Journal of Neurochemistry.

In laboratory experiments, the researchers demonstrated that nicotine inhibits activation of brain immune cells known as microglia. Chronic microglial activation is a sign of brain inflammation that is a key step in nerve cell death. The researchers also identified the specific site, the alpha-7 acetylcholine receptor subtype, to which nicotine binds to block microglial activation.

"We propose that nicotine`s ability to prevent over activation of microglia may be additional mechanism underlying nicotine`s neuroprotective properties in the brain," said USF neuroscientist R. Douglas Shytle, PhD, lead author of the study.

 "This finding lets us explore a new way of looking at neurodegenerative diseases like Alzheimer`s," said Jun Tan, PhD, MD, principal investigator for the study. "A better understanding of the therapeutic aspects of nicotine may also help us develop drugs that mimic the beneficial action of nicotine without its unwanted side effects."

Nicotine mimics the neurotransmitter acetylcholine, a chemical messenger that is critical to communication between brain cells. Acetylcholine is the major neurotransmitter lost in Alzheimer`s disease.

The prevailing hypothesis among researchers is that nicotine helps protect the brain by binding to nicotinic acetylcholine receptors that sit on the end of nerve terminals. This action by nicotine, similar to turning up the volume of a radio signal, causes brain cells to increase the release of neurotransmitters depleted in diseases like Alzheimer`s and Parkinson`s.

The USF study suggests that nicotine may also protect the brain through another, more indirect route -- by quelling the hyperactivity of immune cells (microglia) that have turned against the brain.

In the normal, healthy brain microglia support and maintain neurons. They also help wipe up excess beta amyloid protein that accumulates in the brain with aging.

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